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Antibiotic therapy for the treatment of preterm labor: a review of the evidence.

Authors :
Thorp JM Jr
Hartmann KE
Berkman ND
Carey TS
Lohr KN
Gavin NI
Hasselblad V
Source :
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2002 Mar; Vol. 186 (3), pp. 587-92.
Publication Year :
2002

Abstract

Objective: The purpose of this study was to evaluate the evidence regarding antibiotics for the treatment of preterm labor.<br />Study Design: Through dual review, we abstracted study design and masking, definitions of preterm labor and pregnancy outcome, patient inclusion/exclusion characteristics, patient demographic characteristics, drug and cointerventions, and numerous birth, maternal, and neonatal outcome measures. We graded the quality of the individual articles and the strength of the evidence for antibiotic benefit.<br />Results: We abstracted data from 14 randomized trials and 1 observational study. Of these studies, 13 trials met the requirements for a meta-analysis. The meta-analysis demonstrated a mixed outcome pattern with small improvements in pregnancy prolongation, estimated gestational age at birth, and birth weight. Data were insufficient to show a beneficial effect on neonatal morbidity or mortality rates.<br />Conclusion: Treatment of preterm labor with antibiotic therapy can prolong gestation. The benefits of antibiotics are small, and there is considerable uncertainty about the optimal agent, route, dosage, and duration of therapy.

Details

Language :
English
ISSN :
0002-9378
Volume :
186
Issue :
3
Database :
MEDLINE
Journal :
American journal of obstetrics and gynecology
Publication Type :
Academic Journal
Accession number :
11904629
Full Text :
https://doi.org/10.1067/mob.2002.121620