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Coronary dilatation reserve in experimental hypertension and chronic heart failure: effects of blockade of the renin-angiotensin system.
- Source :
-
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2001 Dec; Vol. 28 (12), pp. 997-1001. - Publication Year :
- 2001
-
Abstract
- 1. The aim of the present study was to investigate left and right ventricular (LV and RV, respectively) coronary vasodilatation reserve (CVR; fluorescent microsphere technique) in rats with hypertension (spontaneously hypertensive rats (SHR)) or congestive heart failure (CHF) and the effects of early and chronic renin-angiotensin system (RAS) blockade thereupon. 2. In adult SHR, both LV and RV CVR were impaired, especially in the non-hypertrophied RV, the main factor involved being coronary vascular remodelling. Blockade of the RAS normalized both LV and RV CVR, mainly through the prevention of hypertension and suppression of the resulting pericoronary fibrosis. 3. In postischaemic CHF rats, there was an early and severe degradation of LV and RV CVR that developed before any significant vascular remodelling and appeared to be linked to the deterioration of cardiac hypertrophy and haemodynamics. This degradation in CVR further worsened over the longer term due to late-developing pericoronary fibrosis and endothelial dysfunction. Blockade of the RAS had no early effects on LV and RV CVR, but improved RV CVR over the long term, mainly by limiting RV hypertrophy and by preventing the development of pericoronary fibrosis and coronary endothelial dysfunction. 4. In kallikrein-kinin system-deficient mice, CVR was not different from that of wild-type mice, suggesting that this system is not implicated in normal CVR regulation.
- Subjects :
- Animals
Antihypertensive Agents administration & dosage
Antihypertensive Agents pharmacology
Biphenyl Compounds administration & dosage
Biphenyl Compounds pharmacology
Coronary Vessels physiopathology
Gene Deletion
Heart drug effects
Heart Failure physiopathology
Hemodynamics drug effects
Hypertension physiopathology
Irbesartan
Kallikrein-Kinin System physiology
Kallikreins genetics
Kallikreins metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Myocardial Ischemia pathology
Myocardial Ischemia physiopathology
Perindopril administration & dosage
Perindopril pharmacology
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Receptor, Bradykinin B2
Receptors, Bradykinin genetics
Receptors, Bradykinin metabolism
Renin-Angiotensin System drug effects
Tetrazoles administration & dosage
Tetrazoles pharmacology
Coronary Vessels pathology
Heart Failure pathology
Hypertension pathology
Renin-Angiotensin System physiology
Vasodilation drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0305-1870
- Volume :
- 28
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Clinical and experimental pharmacology & physiology
- Publication Type :
- Academic Journal
- Accession number :
- 11903302
- Full Text :
- https://doi.org/10.1046/j.1440-1681.2001.03573.x