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The effects of hydroxy-methyl-glutaryl co-enzyme A reductase inhibitors on platelet thrombus formation.
- Source :
-
Atherosclerosis [Atherosclerosis] 2002 Apr; Vol. 161 (2), pp. 301-6. - Publication Year :
- 2002
-
Abstract
- Background: Hydroxy-methyl-glutaryl co-enzyme A reductase inhibitors (HMG CoA RIs) markedly improve the lipid profile of patients with hypercholesterolemia, but the magnitude and time course of the effect of these drugs on other risk factors for atherosclerosis are not well defined.<br />Methods: We employed a random assignment, double-blind design to compare the effect of 8 weeks of HMG CoA RI therapy with either pravastatin (40 mg QD; n=12) or simvastatin (20 mg QD; n=12) with placebo (n=13) on serum lipids, platelet thrombus formation (PTF), and markers of inflammation and thrombosis in patients with coronary artery disease. PTF was measured using a validated ex vivo perfusion chamber system.<br />Results: Total and LDL cholesterol decreased 20.3 +/- 12.7% and 31.4 +/- 16.5% in the HMG CoA RI group and were unchanged with placebo (P<0.01). Triglycerides also decreased 15.3 +/- 22.5% with HMG CoA RI therapy, but increased 8.4 +/- 30.0% with placebo (P=0.01). PTF increased 54.1 +/- 89.0% with placebo and decreased 8.0 +/- 46.82% with HMG CoA RI treatment (P<0.01).<br />Conclusions: HMG CoA RI therapy with pravastatin or simvastatin reduces PTF after only 8 weeks of therapy. Such lipid effects may contribute to the prompt reduction in cardiovascular events noted in some clinical trials.
- Subjects :
- Aged
Analysis of Variance
Blood Platelets physiology
Chi-Square Distribution
Coronary Artery Disease prevention & control
Coronary Thrombosis prevention & control
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Female
Follow-Up Studies
Humans
Male
Middle Aged
Probability
Reference Values
Treatment Outcome
Blood Platelets drug effects
Coronary Artery Disease drug therapy
Hydroxymethylglutaryl-CoA Reductase Inhibitors administration & dosage
Pravastatin administration & dosage
Simvastatin administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9150
- Volume :
- 161
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 11888512
- Full Text :
- https://doi.org/10.1016/s0021-9150(01)00645-1