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Novel reagents for the sensitive spectrophotometric determination of flutamide, an anticancer drug in pharmaceutical preparations.
- Source :
-
International journal of pharmaceutics [Int J Pharm] 2002 Mar 20; Vol. 235 (1-2), pp. 113-20. - Publication Year :
- 2002
-
Abstract
- Simple and sensitive spectrophotometric methods for the determination of flutamide (FLA) in either pure form or in its pharmaceutical preparations are described. The first method is based on the diazotisation of reduced FLA, followed by coupling with alcoholic iminodibenzyl (IDB) in acid medium to give a purple coloured product having a lambda(max) of 570 nm. In the second method, the diazotisation of reduced FLA followed by coupling with 4-amino-5-hydroxy-2,7-naphthalenedisulphonic acid monosodium salt (AHND) in a buffer medium of pH 12, gives a red coloured product having a lambda(max) of 520 nm. Common excipients used as additives in pharmaceutical preparations do not interfere in the proposed methods. Both the methods are highly reproducible and have been applied to a wide variety of pharmaceutical preparations and the results compare favourably with the reported method.
- Subjects :
- Antineoplastic Agents, Hormonal chemistry
Antineoplastic Combined Chemotherapy Protocols chemistry
Benzylamines analysis
Benzylamines chemistry
Flutamide chemistry
Naphthalenesulfonates analysis
Naphthalenesulfonates chemistry
Pharmaceutical Preparations analysis
Pharmaceutical Preparations chemistry
Spectrophotometry, Ultraviolet methods
Antineoplastic Agents, Hormonal analysis
Antineoplastic Combined Chemotherapy Protocols analysis
Flutamide analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0378-5173
- Volume :
- 235
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- International journal of pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 11879746
- Full Text :
- https://doi.org/10.1016/s0378-5173(01)00975-9