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Effect of rifamycin and tilorone derivatives on Friend virus leukemia in mice.
- Source :
-
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) [Proc Soc Exp Biol Med] 1975 Oct; Vol. 150 (1), pp. 32-5. - Publication Year :
- 1975
-
Abstract
- Several derivatives of rifamycin, and analogs of the tilorone-fluoranthene group were tested for inhibition of splenic enlargement in Friend virus leukemia. At least three members of the rifamycin group caused significant inhibition (31-49%) as did at least three members of the tilorone group (32-48%). These six compounds are among those found by others (6, 7) to be most inhibitory in vitro to the RNA-directed DNA polymerase of oncornaviruses. However our studies do not furnish direct evidence for or against a role of inhibition of the viral enzyme in the suppression of splenomegaly. None of the agents was as effective as methotrexate, which caused 90-92% inhibition. The activity of five of the agents was reduced, rather than enhanced by the injection of adjuvants (M. butyricum and pertussis vaccine). Three of the agents had a subtractive, rather than an additive effect on the inhibition caused by methotrexate alone.
- Subjects :
- Adjuvants, Pharmaceutic
Animals
Friend murine leukemia virus growth & development
Methotrexate pharmacology
Mice
Organ Size
Rifamycins pharmacology
Spleen anatomy & histology
Tilorone analogs & derivatives
Tilorone pharmacology
Fluorenes therapeutic use
Friend murine leukemia virus drug effects
Leukemia, Experimental prevention & control
Rifamycins therapeutic use
Tilorone therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0037-9727
- Volume :
- 150
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 1187708
- Full Text :
- https://doi.org/10.3181/00379727-150-38968