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Defining a future role for radiogenic therapy.
- Source :
-
Cancer treatment reviews [Cancer Treat Rev] 2001 Oct; Vol. 27 (5), pp. 289-94. - Publication Year :
- 2001
-
Abstract
- The goal of cancer therapy is to eliminate the cancer and/or to arrest further growth while decreasing normal tissue toxicity, i.e. to increase the therapeutic ratio. This review focuses on a group of therapeutics that are either (1) directly stimulated by radiation to produce either directly or indirectly cytotoxic agents (i.e. genes under the control of a radiation inducible promoter that produce a cytotoxic protein or an enzyme that converts a prodrug to an active form, respectively); (2) auger-electron emitting radiolabelled oligonucleotides, antibodies, nucleotide analogues, or other small molecules that are internalized; (3) radiation inducible genes that produce a ligand or transporter (or the like) which then can be targeted by cytotoxic agents (e.g. radiolabelled substance). We have termed this group of therapeutics radiogenic therapy.<br /> (Copyright 2001 Harcourt Publishers Ltd.)
Details
- Language :
- English
- ISSN :
- 0305-7372
- Volume :
- 27
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cancer treatment reviews
- Publication Type :
- Academic Journal
- Accession number :
- 11871865
- Full Text :
- https://doi.org/10.1053/ctrv.2001.0236