D-Secoestrone derivatives. VI. 17 beta-Benzyl-17 alpha-hydroxy-3-methoxyestra-1,3,5(10)-trien-16-one.

Authors :: Stanković S
Lazar D
Medić-Mijacević L
Penov-Gasi K
Sakac M
Andrić S
Milenko B
Source :: Acta crystallographica. Section C, Crystal structure communications [Acta Crystallogr C] 2002 Mar; Vol. 58 (Pt 3), pp. o172-3. Date of Electronic Publication: 2002 Feb 20.
Publication Year :: 2002
Abstract: The title molecule, C(26)H(30)O(3), shows a novel chemical rearrangement of the substituents at position 17, i.e. an alpha-orientation of the hydroxy group and a beta-orientation of the bulky benzyl moiety. The packing arrangement consists of coils formed by O(2)...O(3) hydrogen bonds along the c axis. The compound shows complete loss of oestrogenic activity, and neither does it exhibit an antagonistic effect.

Subjects :: Estrone analogs & derivatives
Hydrogen Bonding
Models, Molecular
Molecular Conformation
Estradiol Congeners chemistry
Estrone chemistry

Language :: English
ISSN :: 0108-2701
Volume :: 58
Issue :: Pt 3
Database :: MEDLINE
Journal :: Acta crystallographica. Section C, Crystal structure communications
Publication Type :: Academic Journal
Accession number :: 11870318
Full Text :: https://doi.org/10.1107/s0108270101020807

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