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Effect of nafenopin (SU-13,437) on liver function: mechanism of choleretic effect.
- Source :
-
Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 1975; Vol. 290 (2-3), pp. 221-34. - Publication Year :
- 1975
-
Abstract
- Administration of nafenopin (SU-13-437) to male rats for two days leads to a doubling of bile production and a 50% increase in liver weight. These two effects have been shown not to be directly interrelated. A marked decrease in biliary salt concentration suggests that the bile salt independent flow is stimulated. The extra bile produced is probably of canalicular origin since bile to plasma concentration ratios of erythritol are unchanged. At least three polar metabolites of nafenopin have been observed in rat bile. Observations in rats with partial biliary fistulas indicate that the drug and its metabolites undergo extensive entero-hepatic circulation. Our studies support the view that much of the enhanced bile flow is associated with the presence of nafenopin and/or its metabolites within the hepatobiliary system. However, the response is too extensive to be explained merely by osmotic choleresis. Induced structural changes in the liver may also account forsome of this effect.
- Subjects :
- Animals
Bile analysis
Bile Acids and Salts analysis
Bile Ducts, Intrahepatic metabolism
Biliary Fistula
Body Water drug effects
Body Weight drug effects
Enterohepatic Circulation
Erythritol metabolism
Kinetics
Liver metabolism
Male
Nafenopin metabolism
Organ Size drug effects
Plasma Volume drug effects
Rats
Sodium analysis
Bile metabolism
Liver drug effects
Nafenopin pharmacology
Propionates pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0028-1298
- Volume :
- 290
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Naunyn-Schmiedeberg's archives of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 1186921
- Full Text :
- https://doi.org/10.1007/BF00510552