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Evaluation of renal function following treatment with 5-aminosalicylic acid derivatives in patients with ulcerative colitis.
- Source :
-
Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2002 Feb; Vol. 16 (2), pp. 207-15. - Publication Year :
- 2002
-
Abstract
- Background: A number of cases of nephrotoxicity have been reported in patients with inflammatory bowel disease taking oral 5-aminosalicylic acid (5-ASA).<br />Aim: To evaluate the effects of 9 months of therapy with mesalazine or olsalazine on renal function in patients with ulcerative colitis in remission.<br />Methods: Forty patients with ulcerative colitis in complete remission for 6 months were randomized to either olsalazine (n=20) or mesalazine (n=20 for nine months). Thirty-six of the 40 patients were on prior salicylate therapy. Disease activity was the measure ofclinical efficacy and was assessed by the Harvey-Bradshaw Index (HBI). Laboratory efficacy measurements included glomerular filtration rate (GFR), microalbuminuria, urinary gluthathione S-transferase (GST) and serum C-reactive protein (CRP). Safety analysis consisted of documentation of adverse events and laboratory values.<br />Results: There was no significant reduction in the GFR overall on therapy. The levels of GFR adjusted for baseline were similar in the two treatment groups after 3, 6 and 9 months. A significantly higher percentage of mesalazine-treated patients experienced drug related adverse events, all of a minor nature. The incidence of adverse events causing early withdrawal was similar in the two treatment groups.<br />Conclusion: Treatment with mesalazine or olsalazine for 9 months had no significant impact on GFR.
- Subjects :
- Adult
Aminosalicylic Acids therapeutic use
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Female
Glomerular Filtration Rate drug effects
Humans
Male
Mesalamine therapeutic use
Middle Aged
Albuminuria chemically induced
Aminosalicylic Acids adverse effects
Anti-Inflammatory Agents, Non-Steroidal adverse effects
Colitis, Ulcerative drug therapy
Kidney drug effects
Mesalamine adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0269-2813
- Volume :
- 16
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Alimentary pharmacology & therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 11860403
- Full Text :
- https://doi.org/10.1046/j.1365-2036.2002.01155.x