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Effects of growth hormone treatment on left ventricular dimensions in children with Noonan's syndrome.
- Source :
-
Hormone research [Horm Res] 2001; Vol. 56 (3-4), pp. 110-3. - Publication Year :
- 2001
-
Abstract
- Objective: To study the effects of long-term growth hormone (GH) treatment on left ventricular (LV) dimensions in children with Noonan's syndrome (NS).<br />Methods: Echocardiographic measurements of LV dimensions were performed before and during GH treatment in 27 participants (21 boys, 6 girls) in a partly controlled 3-year trial of high-dose GH treatment (0.15 IU/kg/day). Nineteen children had a congenital heart defect, 1 of them had hypertrophic obstructive cardiomyopathy. In the first 3 years, the children were assigned to 1 of 2 groups: group A with discontinuation of GH treatment in the 3rd year, or group B without GH treatment in the 1st year. After the 3rd year, 12 of the 27 children were followed up for 2 additional years to evaluate the long-term effects of GH treatment on the heart.<br />Results: At baseline, LV internal diameters were smaller, while posterior wall thickness were thicker than normal. Over the 1st year, changes in LV dimensions were comparable between the 2 groups. No significant differences were found in LV dimensions between the situation at baseline and after 4 years of GH treatment.<br />Conclusion: Long-term high-dose GH treatment does not have clinically significant adverse effects on LV dimensions in children with NS.<br /> (Copyright 2002 S. Karger AG, Basel)
Details
- Language :
- English
- ISSN :
- 0301-0163
- Volume :
- 56
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Hormone research
- Publication Type :
- Academic Journal
- Accession number :
- 11847472
- Full Text :
- https://doi.org/10.1159/000048101