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DNA double-strand break repair from head to tail.
- Source :
-
Current opinion in structural biology [Curr Opin Struct Biol] 2002 Feb; Vol. 12 (1), pp. 115-22. - Publication Year :
- 2002
-
Abstract
- DNA double-strand break repair is a complex process that requires multiple enzymatic and structural activities to rejoin or repair the broken DNA ends using one of several repair pathways. These enzymatic and structural activities include end detection, end processing and alignment of DNA ends. Recent structural and functional studies of the DNA double-strand break repair factors Mre11/Rad50, Ku70/80 and Xrcc4 show how these enzymes combine and assemble both enzymatic and structural activities in DNA double-strand break repair.
- Subjects :
- Adenosine Triphosphate metabolism
Archaeal Proteins chemistry
DNA metabolism
DNA-Binding Proteins chemistry
Endodeoxyribonucleases chemistry
Exodeoxyribonucleases chemistry
Ku Autoantigen
Nuclear Proteins chemistry
Protein Conformation
Antigens, Nuclear
Archaeal Proteins physiology
DNA Helicases
DNA Repair physiology
DNA-Binding Proteins physiology
Endodeoxyribonucleases physiology
Exodeoxyribonucleases physiology
Nuclear Proteins physiology
Saccharomyces cerevisiae Proteins
Subjects
Details
- Language :
- English
- ISSN :
- 0959-440X
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Current opinion in structural biology
- Publication Type :
- Academic Journal
- Accession number :
- 11839498
- Full Text :
- https://doi.org/10.1016/s0959-440x(02)00297-x