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Comparison of gadobenate dimeglumine and gadopentetate dimeglumine: a study of MR imaging and inductively coupled plasma atomic emission spectroscopy in rat brain tumors.
- Source :
-
AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2002 Jan; Vol. 23 (1), pp. 15-8. - Publication Year :
- 2002
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Abstract
- Background and Purpose: After the advent of extracellular contrast media, hepatobiliary-specific gadolinium chelates were developed to improve the diagnostic value of MR imaging of the liver. Gadobenate dimeglumine (Gd-BOPTA) is a new paramagnetic contrast agent with partial biliary excretion that produces prolonged enhancement of liver parenchyma on T1-weighted images. However, whether Gd-BOPTA is useful as a contrast agent in central nervous system disease, particularly in brain tumors, is unclear.<br />Methods: The behavior of Gd-BOPTA as a brain tumor-selective contrast agent was compared with that of gadopentetate dimeglumine (Gd-DTPA), an MR contrast agent used in central nervous system disease, in a common dose of 0.1 mmol/kg. An MR imaging study of these two contrast agents was performed, and tissue concentrations were measured with inductively coupled plasma atomic emission spectroscopy (ICP-AES).<br />Results: Gd-BOPTA showed better MR imaging enhancement in brain tumors than did Gd-DTPA at every time course until 2 hours after administration and no enhancement in peritumoral tissue and normal brain. Corresponding results with ICP-AES showed significantly greater uptake of Gd-BOPTA in tumor samples than that in peritumoral tissue and normal brain 5 minutes after administration. Gadolinium was retained for a longer time in brain tumors when Gd-BOPTA rather than Gd-DTPA was administered.<br />Conclusion: Gd-BOPTA is a useful contrast agent for MR imaging in brain tumors and possibly an effective absorption agent for neutron capture therapy.
- Subjects :
- Animals
Brain pathology
Humans
Male
Meglumine pharmacokinetics
Metabolic Clearance Rate
Rats
Rats, Inbred F344
Spectrophotometry, Atomic
Brain Neoplasms diagnosis
Contrast Media pharmacokinetics
Gadolinium DTPA pharmacokinetics
Glioma diagnosis
Image Enhancement
Magnetic Resonance Imaging
Meglumine analogs & derivatives
Organometallic Compounds pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 0195-6108
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- AJNR. American journal of neuroradiology
- Publication Type :
- Academic Journal
- Accession number :
- 11827870