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Micrometastasis in the bone marrow of patients with lung cancer associated with a reduced expression of E-cadherin and beta-catenin: risk assessment by immunohistochemistry.
- Source :
-
Surgery [Surgery] 2002 Jan; Vol. 131 (1 Suppl), pp. S226-31. - Publication Year :
- 2002
-
Abstract
- Background: The presence of disseminated tumor cells in bone marrow is considered to be a premetastatic state, which is called micrometastasis. To evaluate the relationship between micrometastasis and cellular adhesion molecules in the primary lesion, E-cadherin and beta-catenin were immunohistochemically investigated. Methods. Fifty-eight patients with non-small cell lung cancer who underwent a complete resection were entered into this study. Tumor cells in bone marrow aspirates were detected by immunohistochemistry using cytokeratin (CK) 18. Immunohistochemical studies of E-cadherin and beta-catenin were performed in the corresponding primary tumor.<br />Results: CK-positive cells were detected in the bone marrow aspirates from 27 of 58 patients. A reduced expression of the E-cadherin and beta-catenin was found in 16 (27.6%) and in 22 (37.9%) of 58 patients, respectively. In 26 cases with a reduced expression of E-cadherin and/or beta-catenin, 16 cases had CK-positive cells, whereas 11 of 32 cases with normal expression of both factors had CK-positive cells (P=.0392). The patients with micrometastasis demonstrated an earlier recurrence (P =.0642) and a significantly poorer survival (P =.0437) than those without such cells.<br />Conclusions: Micrometastasis in the bone marrow might be a significant predictor of poor prognosis, and a reduced expression of E-cadherin and beta-catenin are important determinants for the metastatic capability of individual cancer cells.
- Subjects :
- Adenocarcinoma mortality
Adult
Aged
Aged, 80 and over
Bone Marrow Neoplasms mortality
Cadherins analysis
Carcinoma, Squamous Cell mortality
Carcinoma, Squamous Cell secondary
Cytoskeletal Proteins analysis
Disease-Free Survival
Female
Humans
Immunohistochemistry
Keratins analysis
Lung Neoplasms mortality
Lung Neoplasms physiopathology
Male
Middle Aged
Predictive Value of Tests
Prognosis
Risk Factors
Survival Rate
beta Catenin
Adenocarcinoma secondary
Bone Marrow Neoplasms secondary
Cadherins biosynthesis
Cytoskeletal Proteins biosynthesis
Lung Neoplasms pathology
Trans-Activators
Subjects
Details
- Language :
- English
- ISSN :
- 0039-6060
- Volume :
- 131
- Issue :
- 1 Suppl
- Database :
- MEDLINE
- Journal :
- Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 11821816
- Full Text :
- https://doi.org/10.1067/msy.2002.119793