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Intratympanic gentamicin therapy for persistent vertigo after endolymphatic sac surgery.
- Source :
-
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery [Otolaryngol Head Neck Surg] 2002 Jan; Vol. 126 (1), pp. 31-3. - Publication Year :
- 2002
-
Abstract
- Objectives: To evaluate the role of intratympanic gentamycin therapy (ITGM) in controlling vertigo in patients with refractory Meniere's who have recurrent or persistent vertigo after endolymphatic sac surgery.<br />Study Design and Setting: A retrospective review of 491 patients seen in a university balance clinic between July 1999 and July 2000. Of these, 68 patients had Meniere's disease; 4 patients had recurrent vertigo after endolymphatic sac surgery and were followed for at least 1 year. These 4 patients received a series of ITGM injections. Outcome measures included control of vertigo and audiometric results.<br />Results: Three of 4 (75%) patients had control of their vertigo with ITGM therapy. The 1 patient who failed ITGM therapy underwent a successful vestibular neurectomy with ultimate control of his vertigo. No patients had progression of their sensorineural hearing loss.<br />Conclusion: ITGM therapy can be used to control vertigo in selected patients with Meniere's disease who have persistent vertigo after unsuccessful endolymphatic sac surgery.<br />Significance: ITGM therapy may reduce the need for vestibular neurectomy in patients with refractory Meniere's disease after endolymphatic sac surgery.
- Subjects :
- Administration, Topical
Adult
Anti-Bacterial Agents administration & dosage
Audiometry, Pure-Tone
Electronystagmography
Endolymphatic Sac physiopathology
Female
Gentamicins administration & dosage
Hearing Loss, Sensorineural diagnosis
Hearing Loss, Sensorineural physiopathology
Humans
Male
Meniere Disease physiopathology
Recurrence
Retrospective Studies
Severity of Illness Index
Speech Discrimination Tests
Speech Perception
Tympanic Membrane
Vestibular Nerve physiopathology
Vestibular Nerve surgery
Anti-Bacterial Agents therapeutic use
Endolymphatic Sac surgery
Gentamicins therapeutic use
Meniere Disease surgery
Postoperative Complications
Vertigo drug therapy
Vertigo etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0194-5998
- Volume :
- 126
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 11821762
- Full Text :
- https://doi.org/10.1067/mhn.2002.119677