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The integrin alphaVbeta6 binds and activates latent TGFbeta3.
- Source :
-
FEBS letters [FEBS Lett] 2002 Jan 30; Vol. 511 (1-3), pp. 65-8. - Publication Year :
- 2002
-
Abstract
- Transforming growth factors-beta (TGFbeta1, 2 and 3) are secreted in a complex with their propeptides (latency-associated peptide 1 (LAP1), 2 and 3). TGFbeta signaling requires the dissociation of LAP and TGFbeta, a process termed latent TGFbeta activation. This process is a critical but incompletely understood step in the regulation of TGFbeta function. In particular, the extent to which activation mechanisms differ among the three TGFbeta isoforms is relatively unexplored. We show here that alphaVbeta6 binds and activates latent TGFbeta3.
- Subjects :
- Animals
Cell Line
Gene Deletion
Ligands
Mice
Mink
Oligopeptides genetics
Oligopeptides metabolism
Protein Binding
Protein Isoforms chemistry
Protein Isoforms genetics
Protein Isoforms metabolism
Protein Isoforms pharmacology
Proteins metabolism
Substrate Specificity
TNF Receptor-Associated Factor 2
Transfection
Transforming Growth Factor beta chemistry
Transforming Growth Factor beta genetics
Transforming Growth Factor beta pharmacology
Transforming Growth Factor beta1
Transforming Growth Factor beta3
Antigens, Neoplasm
Integrins metabolism
Transforming Growth Factor beta metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0014-5793
- Volume :
- 511
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 11821050
- Full Text :
- https://doi.org/10.1016/s0014-5793(01)03280-x