Back to Search
Start Over
Sex- and strain-dependent histological features of the proximal convoluted tubular epithelium of mouse kidney: association with lysosomes containing apolipoprotein B.
- Source :
-
Histology and histopathology [Histol Histopathol] 2002 Jan; Vol. 17 (1), pp. 1-7. - Publication Year :
- 2002
-
Abstract
- In the present study, we performed comparative histological observations of ICR, BALB/c, C57BL/6, C3H/HeN and DBA/2 mice kidneys. Sex and strain differences were observed in the appearance of vacuolar structures of the proximal convoluted tubules (toluidine blue-positive granules in osmium-postfixed epoxy-resin sections). These features were especially remarkable in male DBA/2 mice. The vacuolar structures in male DBA/2 mice showed heterogeneous staining with Sudan B in frozen sections and appeared under an electron microscope as multilammelar giant dense bodies. In addition, these dense bodies showed heterogeneous acid phosphatase reactions. Immunohistochemical analyses of these structures for apolipoprotein B showed strong positive reactions. These results suggested that vacuolar structures in the proximal convoluted tubules, which were remarkable in male DBA/2 mice, were giant lysosomes containing apolipoprotein B.
- Subjects :
- Acid Phosphatase chemistry
Acid Phosphatase metabolism
Animals
Epithelium anatomy & histology
Female
Immunohistochemistry
Male
Mice
Mice, Inbred Strains
Microscopy, Electron
Paraffin Embedding
Sex Characteristics
Species Specificity
Vacuoles ultrastructure
Apolipoproteins B metabolism
Kidney Tubules, Proximal anatomy & histology
Lysosomes metabolism
Lysosomes ultrastructure
Subjects
Details
- Language :
- English
- ISSN :
- 0213-3911
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Histology and histopathology
- Publication Type :
- Academic Journal
- Accession number :
- 11813859
- Full Text :
- https://doi.org/10.14670/HH-17.1