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MRP 8/14 and procalcitonin serum levels in organ transplantations.
- Source :
-
Annals of transplantation [Ann Transplant] 2001; Vol. 6 (2), pp. 6-9. - Publication Year :
- 2001
-
Abstract
- Objectives: MRP8/14 is a heterodimer of two myeloid calcium-binding proteins associated with different types of acute inflammatory processes. We studied MRP8/14 together with procalcitonin (PCT) serum levels in order to diagnose infectious complications or the rejection process affecting kidney or heart allograft.<br />Methods: A total of 419 serum samples was evaluated. MRP8/14 levels were measured by ELISA (BMA Biomed), PCT by a sensitive immunoluminiscent assay ILMA (Brahms Diagn.)<br />Results: Both parameters showed very low basal levels in healthy subjects (range 303-1,660 ng/ml of MRP8/14; less than 0.08 ng/ml of PCT). A rapid increase in serum levels occurred in response to bacterial infections (MRP8/14 up to 6,230 ng/ml; PCT up to 297 ng/ml). Serum PCT concentration remained low in the presence of kidney allograft rejection, where MRP8/14 levels were increased. An uncomplicated outcome of kidney or heart transplantation did not change basal serum MRP8/14 and PCT levels.<br />Conclusions: We conclude that 1) both MRP8/14 and PCT are very sensitive markers of complications in organ transplant recipients (normal values in uncomplicated outcome) 2) combination of both parameters is useful to discriminate between rejection (increased MRP8/14 with normal PCT) and systemic bacterial infection (both parameters increased).
- Subjects :
- Aged
Biomarkers blood
Calcitonin Gene-Related Peptide
Calgranulin A
Calgranulin B
Dimerization
Humans
Inflammation
Male
Middle Aged
Reference Values
Antigens, Differentiation blood
Calcitonin blood
Calcium-Binding Proteins blood
Organ Transplantation physiology
Protein Precursors blood
S100 Proteins blood
Subjects
Details
- Language :
- English
- ISSN :
- 1425-9524
- Volume :
- 6
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Annals of transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 11803621