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Characterization of a novel salivary immunosuppressive protein from Ixodes ricinus ticks.
- Source :
-
The Journal of biological chemistry [J Biol Chem] 2002 Mar 22; Vol. 277 (12), pp. 10083-9. Date of Electronic Publication: 2002 Jan 15. - Publication Year :
- 2002
-
Abstract
- In tick salivary glands, several genes are induced during the feeding process, leading to the expression of new proteins. These proteins are typically secreted in tick saliva and are potentially involved in the modulation of the host immune and hemostatic responses. In a previous study, the construction and the analysis of a subtractive library led to the identification of Ixodes ricinus immunosuppressor (Iris), a novel protein, differentially expressed in I. ricinus salivary glands during the blood meal. In the present study, the data strongly suggest that this protein is secreted by tick salivary glands into the saliva. In addition, Iris is also found to modulate T lymphocyte and macrophage responsiveness by inducing a Th2 type response and by inhibiting the production of pro-inflammatory cytokines. In conclusion, these results suggest that Iris is an immunosuppressor, which might play an important role in the modulation of host immune response.
- Subjects :
- Animals
CD28 Antigens biosynthesis
CD3 Complex biosynthesis
CHO Cells
Cell Division
Cells, Cultured
Cricetinae
Cytokines biosynthesis
DNA, Complementary metabolism
Dose-Response Relationship, Drug
Humans
Interferon-gamma biosynthesis
Interleukin-10 biosynthesis
Interleukin-5 biosynthesis
Ixodes
Macrophages metabolism
Mice
Mice, Inbred BALB C
Microscopy, Confocal
Protein Binding
Protein Structure, Tertiary
Salivary Glands metabolism
Spleen cytology
T-Lymphocytes metabolism
Th2 Cells metabolism
Immunosuppressive Agents pharmacology
Saliva metabolism
Salivary Proteins and Peptides biosynthesis
Salivary Proteins and Peptides chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9258
- Volume :
- 277
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Journal of biological chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 11792703
- Full Text :
- https://doi.org/10.1074/jbc.M111391200