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Modulation of radiation-induced protein kinase C activity by phenolics.
- Source :
-
Journal of radiological protection : official journal of the Society for Radiological Protection [J Radiol Prot] 2001 Dec; Vol. 21 (4), pp. 361-70. - Publication Year :
- 2001
-
Abstract
- Natural phenolic compounds were tested in vitro for their effect on the activity of protein kinase C (PKC) isolated from the liver cytosol and the particulate fraction of unirradiated mice and mice irradiated at 5 Gy. Following irradiation, the PKC activity was found to be increased in both cytosolic and particulate fractions. Curcumin, ellagic acid and quercetin were effective in inhibiting radiation-induced PKC activity. Curcumin and ellagic acid were found to be more inhibitory towards radiation-induced PKC activity, while quercetin was the least effective. Curcumin was found to inhibit the activated cytosolic and particulate PKC at very low concentrations. Activation of PKC is one of the means of conferring radioresistance on a tumour cell. Suppression of PKC activity by phenolics may be one of the means of preventing the development of radioresistance following radiotherapy.
Details
- Language :
- English
- ISSN :
- 0952-4746
- Volume :
- 21
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of radiological protection : official journal of the Society for Radiological Protection
- Publication Type :
- Academic Journal
- Accession number :
- 11787891
- Full Text :
- https://doi.org/10.1088/0952-4746/21/4/304