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[Somatostatin analogues for the treatment of gastro-entero-pancreatic neuroendocrine tumours].
- Source :
-
Minerva endocrinologica [Minerva Endocrinol] 2001 Dec; Vol. 26 (4), pp. 225-9. - Publication Year :
- 2001
-
Abstract
- Somatostatin has represented a significant breakthrough in the treatment of patients with hormone-acting, neuroendocrine gastro-intestinal-pancreatic (NEGEP) neoplasms, even if its short half-life made it impractical in the clinical practice. Over the last recent years new long-acting formulations have been developed from the native peptide. Octreotide, lanreotide and vapeotide are octapeptides with similar biological activity, remarkable stability and longer half-life; an extended-release formulation of octreotide (Octreotide-LAR) and lanreotide (Lanreotide-SR) have been more recently developed by incorporating the peptide in microspheres of a biodegradable polymer. This formulation was conceived to provide patients with the convenience of a once-a-month or twice-a-month injection and to ensure a stable serum concentration between injections and good clinical control of NEGEP tumours symptoms. Nowadays, somatostatin long-acting analogues represent the first treatment option in those patients who doesn't underwent radical surgery; in addition, these substances present no important side effects, ameliorate the prognosis and can exert some degree of tumour growth control.
Details
- Language :
- Italian
- ISSN :
- 0391-1977
- Volume :
- 26
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Minerva endocrinologica
- Publication Type :
- Academic Journal
- Accession number :
- 11782707