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Influence of human immunodeficiency virus type 1 infection on acute hepatitis A virus infection.
- Source :
-
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2002 Feb 01; Vol. 34 (3), pp. 379-85. Date of Electronic Publication: 2001 Dec 14. - Publication Year :
- 2002
-
Abstract
- To assess the possible influence of human immunodeficiency virus type 1 (HIV-1) infection on the clinical course of acute hepatitis A virus (HAV) infection, 15 HIV-1-infected homosexual men and 15 non-HIV-infected age-matched subjects were compared. HAV load was higher in HIV-1-infected than in non-HIV-infected patients (P<.001). Duration of viremia in HIV-1-infected patients (median, 53 days) was significantly (P<.05) longer than in non-HIV-infected patients (median, 22 days). HIV-1-infected patients had lower elevations in alanine aminotransferase levels than did non-HIV-infected patients (P<.01) but had higher elevations in alkaline phosphatase levels than did non-HIV-infected patients (P<.001). Some HIV-1-infected patients still had HAV viremia when clinical symptoms had disappeared and alanine aminotransferase levels had returned to normal (60-90 days after the onset of symptoms). HIV-1 infection was associated with prolongation of HAV viremia, which might cause a long-lasting outbreak of HAV infection in HIV-1-infected homosexual men.
- Subjects :
- Acute Disease
Adult
Alanine Transaminase metabolism
Aspartate Aminotransferases metabolism
Female
HIV Infections virology
Hepatitis A virus genetics
Homosexuality
Humans
Male
Middle Aged
Polymerase Chain Reaction
Serologic Tests
Viral Load
Viremia virology
HIV Infections complications
HIV-1 physiology
Hepatitis A etiology
Hepatitis A virus physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6591
- Volume :
- 34
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Publication Type :
- Academic Journal
- Accession number :
- 11774086
- Full Text :
- https://doi.org/10.1086/338152