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Gel-Phase synthesis of hydrophobic (thr14) (thr19) galanin (1 -19) fragment on a high capacity flexible crosslinked polystyrene support.
- Source :
-
Journal of peptide science : an official publication of the European Peptide Society [J Pept Sci] 2001 Nov; Vol. 7 (11), pp. 606-12. - Publication Year :
- 2001
-
Abstract
- A hydrophobic analogue of human galanin (1-19) fragment has been synthesized using Boc/Bzl tactics to demonstrate the synthetic utility of the flexible crosslinked polystyrene support prepared by the suspension polymerization of styrene and 1,4-butanediol dimethacrylate. The copolymer was chloromethylated to 2.36 mmol Cl/g. The functionalized resin was found to possess all the physicochemical properties similar to Merrifield resin. The free peptide was obtained in high yield and purity as judged by RP-HPLC and characterized by amino acid analysis and ESI-MS.
Details
- Language :
- English
- ISSN :
- 1075-2617
- Volume :
- 7
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of peptide science : an official publication of the European Peptide Society
- Publication Type :
- Academic Journal
- Accession number :
- 11763365
- Full Text :
- https://doi.org/10.1002/psc.357