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Time independence of the prognostic impact of tumor cell detection in the bone marrow of primary breast cancer patients.
- Source :
-
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2001 Dec; Vol. 7 (12), pp. 4102-8. - Publication Year :
- 2001
-
Abstract
- Purpose: Tumor cell detection (TCD) in bone marrow is an outstanding prognostic factor in breast cancer. There is only one other study that has investigated more than 300 patients with a median follow-up of more than 5 years (J. L. Mansi et al., Lancet, 354:197-202, 1999). We report data from 727 patients with a median follow-up period of 6.5 years.<br />Experimental Design: In a prospective study, intraoperatively aspirated bone marrow was screened for micrometastatic cancer cells. We used an immunocytological method (monoclonal mucin antibody 2E11; the avidin-biotin complex method).<br />Results: Forty-three percent of the patients were TCD positive. Sixty percent of the patients with distant metastases were tumor cell positive (155 of 258 patients). Forty-nine percent of the patients with positive TCD developed distant metastases (155 of 315 patients). TCD was an independent prognostic factor for clinical outcome after a median follow-up time of 6.5 years. The prognostic impact of TCD and tumor size remains constant with the time, whereas the impact of grading and progesterone receptor on risk seems to decrease with longer follow-up time.<br />Conclusions: TCD remains an independent prognostic factor The impact of TCD does not change with longer follow-up time. TCD is a reliable prognostic factor and provides important information about the process of metastasis.
- Subjects :
- Adult
Aged
Aged, 80 and over
Antineoplastic Agents, Hormonal therapeutic use
Breast Neoplasms drug therapy
Breast Neoplasms mortality
Breast Neoplasms surgery
Chemotherapy, Adjuvant
Disease-Free Survival
Female
Goserelin therapeutic use
Humans
Immunohistochemistry
Lymph Node Excision
Lymphatic Metastasis
Middle Aged
Prognosis
Retrospective Studies
S Phase
Survival Rate
Tamoxifen therapeutic use
Time Factors
Bone Marrow pathology
Bone Marrow Cells pathology
Breast Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1078-0432
- Volume :
- 7
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Clinical cancer research : an official journal of the American Association for Cancer Research
- Publication Type :
- Academic Journal
- Accession number :
- 11751508