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Three new vanadyl(IV) complexes with non-steroidal anti-inflammatory drugs (Ibuprofen, Naproxen and Tolmetin). Bioactivity on osteoblast-like cells in culture.
- Source :
-
Journal of inorganic biochemistry [J Inorg Biochem] 2002 Jan 01; Vol. 88 (1), pp. 94-100. - Publication Year :
- 2002
-
Abstract
- The synthesis and spectral and magnetic characterization of VO(2+) complexes with Ibuprofen (2-(4-isobutylphenyl)propionic acid), Naproxen (6-methoxy-alpha-methyl-2-naphthalene acetic acid) and Tolmetin (1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid) were studied. The complexes [VO(Ibu)(2)] x 5CH(3)OH, [VO(Nap)(2)] x 5CH(3)OH and [VO(Tol)(2)] were obtained from methanolic solutions under nitrogen atmosphere. The biological activities of these complexes on the proliferation of two osteoblast-like cells in culture (MC3T3E1 and UMR106) were compared with that of the vanadyl(IV) cation. The complexes exhibited different effects depending on the concentration and the cellular type, while no effect was observed for their parent drugs.
- Subjects :
- Animals
Anti-Inflammatory Agents, Non-Steroidal chemistry
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Cell Division drug effects
Dose-Response Relationship, Drug
Ibuprofen chemistry
Ibuprofen pharmacology
Mice
Naproxen chemistry
Naproxen pharmacology
Organometallic Compounds chemical synthesis
Organometallic Compounds chemistry
Organometallic Compounds pharmacology
Rats
Spectrum Analysis
Tolmetin chemistry
Tolmetin pharmacology
Tumor Cells, Cultured drug effects
Vanadates chemistry
Anti-Inflammatory Agents, Non-Steroidal chemical synthesis
Osteoblasts drug effects
Vanadates chemical synthesis
Vanadates pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0162-0134
- Volume :
- 88
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of inorganic biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 11750030
- Full Text :
- https://doi.org/10.1016/s0162-0134(01)00368-3