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Nocturnal asthma and gastroesophageal reflux.
Nocturnal asthma and gastroesophageal reflux.
- Source :
-
The American journal of medicine [Am J Med] 2001 Dec 03; Vol. 111 Suppl 8A, pp. 31S-36S. - Publication Year :
- 2001
-
Abstract
- Bronchial asthma is a complex disease involving various cyclic environmental and chronobiologic factors. In patients with asthma, nocturnal gastroesophageal reflux (GER) has been associated with triggering and worsening bronchoconstriction. There are data to suggest that the prevalence of GER is higher in patients with asthma than in the general population and that GER is directly associated with asthma severity. However, the role of GER in asthma remains controversial; some studies suggest that reflux does not mediate nocturnal asthma symptoms. This article reports the results from a study conducted in 7 adult patients affected by nocturnal asthma and moderate to severe GER disease. The relation between GER and asthma was tested by continuously and simultaneously monitoring respiratory resistances and esophageal pH. The study demonstrated a significant correlation between lower respiratory resistances and spontaneous GER. More specifically, both long (more than 5 minutes' duration) and short (5 minutes' or less duration) GER episodes elicited bronchoconstriction in patients with asthma who had moderate to severe GER disease. The severity and duration of bronchoconstriction were related to the duration of GER.
- Subjects :
- Adult
Airway Resistance physiology
Asthma diagnosis
Female
Gastroesophageal Reflux diagnosis
Humans
Linear Models
Male
Middle Aged
Polysomnography
Prevalence
Prospective Studies
Respiratory Function Tests
Risk Assessment
Risk Factors
Sensitivity and Specificity
Severity of Illness Index
Time Factors
Asthma etiology
Gastroesophageal Reflux complications
Sleep Apnea Syndromes etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9343
- Volume :
- 111 Suppl 8A
- Database :
- MEDLINE
- Journal :
- The American journal of medicine
- Publication Type :
- Academic Journal
- Accession number :
- 11749921
- Full Text :
- https://doi.org/10.1016/s0002-9343(01)00855-5