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Analgesic effect of endomorphin-1.
- Source :
-
Acta pharmacologica Sinica [Acta Pharmacol Sin] 2001 Nov; Vol. 22 (11), pp. 976-80. - Publication Year :
- 2001
-
Abstract
- Aim: To study the analgesic effect of endomorphin-1 (EM-1).<br />Methods: The experiment was performed in rats and mice to study the analgesic effect of intraperitoneal (ip) injection of EM-1 with tail stimulation-vocalization test, writhing test, adjuvant arthritis, and neuropathic pain model and to compare it with the analgesic effects produced by intracerebroventricular (icv) and intrathecal (it) administrations.<br />Results: 1) EM-1 raised the pain threshold dose-dependently in tail stimulation-vocalization test in rats and inhibited the writhing responses induced by ip acetic acid in mice. EM-1 also decreased the hyperalgesia in both adjuvant arthritis and neuropathic pain model. 2) The analgesic effect induced by central (icv and it) administration of EM-1 was faster and more powerful than that induced by peripheral (ip) administration. 3) The analgesic effect of EM-1 was reversed by naloxone (opioid receptor antagonist), as well as by cyprodime (mu-opioid receptor selective antagonist). Repeated administrations of EM-1 induced tolerance.<br />Conclusion: EM-1 had a definite analgesic effect and the analgesic effect of EM-1 was mediated by central mu-opioid receptor.
- Subjects :
- Analgesics, Opioid therapeutic use
Animals
Arthritis, Experimental complications
Arthritis, Experimental physiopathology
Drug Tolerance
Male
Mice
Oligopeptides therapeutic use
Pain etiology
Pain Measurement
Pain Threshold drug effects
Rats
Receptors, Opioid, mu antagonists & inhibitors
Receptors, Opioid, mu metabolism
Analgesics, Opioid pharmacology
Nociceptors drug effects
Oligopeptides pharmacology
Pain drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1671-4083
- Volume :
- 22
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Acta pharmacologica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- 11749786