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Aversive experiences are associated with a rapid and transient activation of ERKs in the rat hippocampus.
- Source :
-
Neurobiology of learning and memory [Neurobiol Learn Mem] 2002 Jan; Vol. 77 (1), pp. 119-24. - Publication Year :
- 2002
-
Abstract
- The extracellular signal-regulated kinases (ERKs) family of mitogen-activated protein kinases (MAPKs) has been shown to participate in memory formation. We recently found that a hippocampal ERK/MAPK cascade is required for memory formation of an inhibitory avoidance training in rats. Here we reported that this learning task is accompanied by a rapid increase in the phosphorylation of hippocampal p44 MAPK. A single mild foot shock produced a similar effect and three consecutive foot shocks provoked the activation of both p44 and p42 MAPKs. In contrast, a brief exposure to the training box or the habituation to an open field did not alter hippocampal ERK/MAPK levels. Together, these findings indicate that aversive behavioral experiences induced a rapid and transient activation of ERK/MAPKs in the hippocampus.<br /> (Copyright 2002 Elsevier Science.)
Details
- Language :
- English
- ISSN :
- 1074-7427
- Volume :
- 77
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neurobiology of learning and memory
- Publication Type :
- Academic Journal
- Accession number :
- 11749089
- Full Text :
- https://doi.org/10.1006/nlme.2000.4000