Cytotoxic butanolides from the stem bark of Formosan Lindera communis.

Authors :: Tsai IL
Hung CH
Duh CY
Chen JH
Lin WY
Chen IS
Source :: Planta medica [Planta Med] 2001 Dec; Vol. 67 (9), pp. 865-7.
Publication Year :: 2001
Abstract: Two new butanolides, lincomolide A (1), lincomolide B (2), along with seven known compounds, isolinderanolide E, sepesteonol, beta-sitosterol, beta-sitosterol-beta-glucoside, tetradecane, nonanoic acid and decanol, were isolated from the chloroform-soluble portion of the stem bark of Lindera communis. Compound 1 showed cytotoxicity against P-388, KB16 and A549, and 2 exhibited cytotoxicity against P-388 cancer cell lines. Moreover, 1 showed marginal activity against HT-29, and 2 against KB16, A549 and HT-29 cancer cell lines. The structures of these compounds were determined by spectral analyses.