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Calcium sensitizer EMD 57033, but not the beta1-adrenoreceptor agonist dobutamine, increases mechanical efficiency in stunned myocardium.
- Source :
-
Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 2002 Jan; Vol. 39 (1), pp. 61-72. - Publication Year :
- 2002
-
Abstract
- External work, efficiency of energy transfer (EET), and mechanical efficiency (defined as the ratio of external work over myocardial oxygen consumption (MVO2) are reduced in stunned myocardium. We therefore evaluated how inotropic stimulation by dobutamine and the calcium sensitizer EMD 57033 affected the regional stress-strain relationship as, from which contractility (E(es)), external work at the working point (EWwp), maximal external work (EWmax), EETwp (%), and EETmax are determined. Thirty minutes after regional stunning in 11 open chest pigs by two 10-min coronary occlusions separated by 10 min of reperfusion, dobutamine (0.5, 1, and 2 microg x kg(-1) x min(-1)) was infused, after an ample washout period followed by infusion of EMD 57033 (0.05, 0.1, 0.2 mg x kg(-1) x min(-1)). Stunning decreased E(es) (30%), EWwp (56%), EWmax (63%), EETwp (34%), EETmax (33%) and mechanical efficiency (55%), but MVO2 was unaffected. EWwp, EWmax, EETwp, and EETmax increased similarly with the two drugs, whereas MVO2 increased only after dobutamine. Consequently, mechanical efficiency increased linearly with contractility during EMD 57033 infusion but remained constant during infusion of dobutamine.
- Subjects :
- Animals
Calcium metabolism
Energy Metabolism
Heart physiopathology
Hemodynamics drug effects
Myocardial Contraction drug effects
Oxygen Consumption
Stimulation, Chemical
Swine
Adrenergic beta-Agonists pharmacology
Cardiotonic Agents pharmacology
Dobutamine pharmacology
Heart drug effects
Myocardial Stunning metabolism
Quinolines pharmacology
Thiadiazines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0160-2446
- Volume :
- 39
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of cardiovascular pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 11743229
- Full Text :
- https://doi.org/10.1097/00005344-200201000-00008