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Tazarotene cream for the treatment of facial photodamage: a multicenter, investigator-masked, randomized, vehicle-controlled, parallel comparison of 0.01%, 0.025%, 0.05%, and 0.1% tazarotene creams with 0.05% tretinoin emollient cream applied once daily for 24 weeks.
- Source :
-
Archives of dermatology [Arch Dermatol] 2001 Dec; Vol. 137 (12), pp. 1597-604. - Publication Year :
- 2001
-
Abstract
- Objective: To assess the safety and efficacy of 4 concentrations of tazarotene cream in the treatment of facial photodamage.<br />Design: Prospective weekly multicenter, investigator-masked, randomized, parallel-group study.<br />Setting: University hospitals and clinical research centers.<br />Patients: Three hundred forty-nine subjects with facial photodamage.<br />Intervention: Daily topical application of tazarotene cream (0.01%, 0.025%, 0.05%, and 0.1%) compared with its vehicle and with 0.05% tretinoin emollient cream.<br />Results: Tazarotene cream and tretinoin cream significantly improved mottled hyperpigmentation and fine wrinkles. At week 24, treatment success rates based on global responses were 67% (39 of 58 subjects) with 0.1% tazarotene, 52% (30 of 58 subjects) with 0.05% tazarotene, 36% (21 of 58 subjects) with 0.025% tazarotene, 41% (24 of 59 subjects) with 0.01% tazarotene, 55% (32 of 58 subjects) with 0.05% tretinoin, and 22% (13 of 58 subjects) with vehicle. Local adverse events, although more frequent with tazarotene at higher concentrations, were generally mild to moderate.<br />Conclusions: Tazarotene in a cream formulation is safe and is associated with positive changes in the treatment of photodamaged facial skin.
- Subjects :
- Administration, Cutaneous
Adult
Dermatologic Agents administration & dosage
Dermatologic Agents blood
Dermatologic Agents pharmacokinetics
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Face
Female
Humans
Hyperpigmentation pathology
Male
Nicotinic Acids administration & dosage
Nicotinic Acids blood
Nicotinic Acids pharmacokinetics
Prospective Studies
Retinoids administration & dosage
Retinoids blood
Retinoids pharmacokinetics
Treatment Outcome
Tretinoin administration & dosage
Tretinoin therapeutic use
United States
Dermatologic Agents therapeutic use
Hyperpigmentation drug therapy
Nicotinic Acids therapeutic use
Retinoids therapeutic use
Skin Aging pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0003-987X
- Volume :
- 137
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Archives of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 11735710
- Full Text :
- https://doi.org/10.1001/archderm.137.12.1597