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In vitro anti-inflammatory effects of quercetin 3-O-methyl ether and other constituents from Rhamnus species.
- Source :
-
Planta medica [Planta Med] 2001 Nov; Vol. 67 (8), pp. 745-7. - Publication Year :
- 2001
-
Abstract
- The anti-inflammatory activities of the isolated flavonoids, quercetin 3-O-methyl ether (1), kaempferol (2), and quercetin (3), of Rhamnus nakaharai, and anthraquinone, frangulin B (4), of Rhamnus formosana, were assessed in vitro by determining their inhibitory effects on the chemical mediators released from mast cells, neutrophils, macrophages, and microglial cells. Compounds 1 - 3 strongly inhibited the release of beta-glucuronidase and lysozyme from rat neutrophils stimulated with formyl-Met-Leu-Phe/cytochalasin B (fMLP/CB). Compound 1 strongly inhibited superoxide anion formation in fMLP/CB or phorbol 12-myristate 13-acetate (PMA)-stimulated rat neutrophils. Compound 1 exhibited potent inhibitory effect on tumor-necrosis factor-alpha ( TNF-alpha) formation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells while 1 and 4 showed potent inhibitory effects on TNF-alpha formation in LPS/IFN-gamma (interferon-gamma)-stimulated murine microglial cell lines N9.
- Subjects :
- Animals
Anthraquinones chemistry
Anthraquinones isolation & purification
Anthraquinones pharmacology
Anti-Inflammatory Agents, Non-Steroidal chemistry
Anti-Inflammatory Agents, Non-Steroidal isolation & purification
Cell Degranulation
Flavonoids chemistry
Flavonoids isolation & purification
Flavonoids pharmacology
Glucuronidase metabolism
Inflammation chemically induced
Macrophages drug effects
Macrophages immunology
Male
Microglia drug effects
Microglia immunology
Molecular Structure
Muramidase metabolism
Neutrophils drug effects
Neutrophils immunology
Phytotherapy
Plant Bark chemistry
Plant Preparations chemistry
Plant Preparations isolation & purification
Plant Preparations pharmacology
Quercetin chemistry
Quercetin isolation & purification
Rats
Structure-Activity Relationship
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Inflammation drug therapy
Kaempferols
Quercetin analogs & derivatives
Quercetin pharmacology
Rhamnus chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0032-0943
- Volume :
- 67
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Planta medica
- Publication Type :
- Academic Journal
- Accession number :
- 11731918
- Full Text :
- https://doi.org/10.1055/s-2001-18339