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T cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TL.
- Source :
-
Science (New York, N.Y.) [Science] 2001 Nov 30; Vol. 294 (5548), pp. 1936-9. - Publication Year :
- 2001
-
Abstract
- The thymus leukemia antigen (TL) is a nonclassical class I molecule, expressed abundantly on intestinal epithelial cells. We show that, in contrast to other major histocompatibility complex (MHC) class I molecules that bind CD8alphabeta, TL preferentially binds the homotypic form of CD8alpha (CD8alphaalpha). Thus, TL tetramers react specifically to CD8alphaalpha-expressing cells, including most intestinal intraepithelial lymphocytes. Compared with CD8alphabeta, which recognizes the same MHC as the T cell receptor (TCR) and thus acts as a TCR coreceptor, high-affinity binding of CD8alphaalpha to TL modifies responses mediated by TCR recognition of antigen presented by distinct MHC molecules. These findings define a novel mechanism of lymphocyte regulation through CD8alphaalpha and MHC class I.
- Subjects :
- Amino Acid Motifs
Animals
Antigen Presentation
CD8 Antigens genetics
CD8 Antigens immunology
CD8-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes metabolism
Enterocytes immunology
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Gene Deletion
H-2 Antigens immunology
Male
Membrane Glycoproteins chemistry
Membrane Glycoproteins immunology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Protein Interaction Mapping
Protein Structure, Tertiary
Receptors, Antigen, T-Cell metabolism
Substrate Specificity
Surface Plasmon Resonance
Tumor Cells, Cultured
CD8 Antigens metabolism
Enterocytes metabolism
H-2 Antigens metabolism
Membrane Glycoproteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 294
- Issue :
- 5548
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 11729321
- Full Text :
- https://doi.org/10.1126/science.1063564