Back to Search
Start Over
No association between dopamine D(2) and D(4) receptor gene variants and antidepressant activity of two selective serotonin reuptake inhibitors.
- Source :
-
Psychiatry research [Psychiatry Res] 2001 Nov 30; Vol. 104 (3), pp. 195-203. - Publication Year :
- 2001
-
Abstract
- The possible association of the dopamine receptor D(2) (Ser 311Cys) and D(4) exon 3 (48 base pair repeat) gene variants with the antidepressant activity of selective serotonin reuptake inhibitors (SSRIs) was investigated in a sample of 364 inpatients affected by a major depressive episode treated with fluvoxamine, 300 mg/day (n=266), or paroxetine, 20-40 mg/day (n=98). The severity of depressive symptoms was assessed weekly with the Hamilton Rating Scale for Depression. Dopamine receptor D(2) (DRD2) and dopamine receptor D(4) (DRD4) allelic variants were determined in each subject by polymerase chain reaction. We observed that DRD2 and DRD4 variants were not associated with response to SSRI treatment. Possible stratification factors, such as sex, diagnosis, presence of psychotic features, depressive symptoms at baseline, paroxetine and fluvoxamine plasma levels, and pindolol augmentation did not significantly influence the observed results. The investigated DRD2 and DRD4 gene variants therefore do not seem to play a major role in the antidepressant activity of SSRIs, at least in the present sample.
- Subjects :
- Depressive Disorder, Major drug therapy
Exons physiology
Female
Fluvoxamine therapeutic use
Gene Frequency genetics
Humans
Male
Middle Aged
Paroxetine therapeutic use
Receptors, Dopamine D4
Selective Serotonin Reuptake Inhibitors therapeutic use
Depressive Disorder, Major genetics
Fluvoxamine pharmacokinetics
Gene Expression genetics
Paroxetine pharmacokinetics
Receptors, Dopamine D2 genetics
Receptors, Dopamine D2 metabolism
Selective Serotonin Reuptake Inhibitors pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 0165-1781
- Volume :
- 104
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Psychiatry research
- Publication Type :
- Academic Journal
- Accession number :
- 11728608
- Full Text :
- https://doi.org/10.1016/s0165-1781(01)00324-9