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Regionally selective alterations in local cerebral glucose utilization evoked by charybdotoxin, a blocker of central voltage-activated K+-channels.
- Source :
-
The European journal of neuroscience [Eur J Neurosci] 2001 Nov; Vol. 14 (9), pp. 1455-63. - Publication Year :
- 2001
-
Abstract
- The quantitative [14C]-2-deoxyglucose autoradiographic technique was employed to investigate the effect of charybdotoxin, a blocker of certain voltage-activated K+ channels, on functional activity, as reflected by changes in local rates of cerebral glucose utilization in rat brain. Intracerebroventricular administration of charybdotoxin, at doses below those producing seizure activity, produced a heterogeneous effect on glucose utilization throughout the brain. Out of the 75 brain regions investigated, 24 displayed alterations in glucose utilization. The majority of these changes were observed with the intermediate dose of charybdotoxin administered (12.5 pmol), with the lower (6.25 pmol) and higher (25 pmol) doses of charybdotoxin producing a much more restricted pattern of change in glucose utilization. In brain regions which displayed alterations in glucose at all doses of charybdotoxin administered, no dose dependency in terms of the magnitude of change was observed. The 21 brain regions which displayed altered functional activity after administration of 12.5 pmol charybdotoxin were predominantly limited to the hippocampus, limbic and motor structures. In particular, glucose utilization was altered within three pathways implicated within learning and memory processes, the septohippocampal pathway, Schaffer collaterals within the hippocampus and the Papez circuit. The nigrostriatal pathway also displayed altered local cerebral glucose utilization. These data indicate that charybdotoxin produces alterations in functional activity within selected pathways in the brain. Furthermore the results raise the possibility that manipulation of particular subtypes of Kv1 channels in the hippocampus and related structures may be a means of altering cognitive processes without causing global changes in neural activity throughout the brain.
- Subjects :
- Animals
Basal Ganglia drug effects
Basal Ganglia metabolism
Brain metabolism
Carbon Radioisotopes
Cerebral Cortex drug effects
Cerebral Cortex metabolism
Dentate Gyrus drug effects
Dentate Gyrus metabolism
Deoxyglucose
Energy Metabolism drug effects
Hippocampus drug effects
Hippocampus metabolism
Limbic System drug effects
Limbic System metabolism
Male
Memory drug effects
Neural Pathways drug effects
Neural Pathways metabolism
Neurons metabolism
Potassium Channels, Voltage-Gated metabolism
Rats
Rats, Long-Evans
Septal Nuclei drug effects
Septal Nuclei metabolism
Brain drug effects
Charybdotoxin pharmacology
Energy Metabolism physiology
Glucose metabolism
Memory physiology
Neurons drug effects
Potassium Channels, Voltage-Gated drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0953-816X
- Volume :
- 14
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The European journal of neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 11722607
- Full Text :
- https://doi.org/10.1046/j.0953-816x.2001.01770.x