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Which bioengineering assay is appropriate for irritant patch testing with sodium lauryl sulfate?
- Source :
-
Contact dermatitis [Contact Dermatitis] 2001 Nov; Vol. 45 (5), pp. 286-90. - Publication Year :
- 2001
-
Abstract
- For testing with sodium lauryl sulphate (SLS), measurements of transepidermal water loss (TEWL) and cutaneous blood flow with laser Doppler (LD) are considered to be the most reliable methods. The aim of this study was to determine which method of measurement should be preferred when conducting SLS testing under varying conditions. Patch testing with SLS at different concentrations and exposure times was performed. TEWL values were compared with those of LD. TEWL values showed distinct changes at low SLS concentrations and short application periods. By contrast, higher SLS concentrations were necessary to increase LD values. Short application of patches changed TEWL rather than LD values. When evaluating SLS patch testing by bioengineering methods, TEWL measurement appears to be more suitable for a test procedure that provokes mild skin reactions (SLS concentration <1%), whereas LD measurement is more appropriate to evaluate pronounced skin reactions (SLS concentration >or=1%).
- Subjects :
- Dermatitis, Irritant etiology
Dose-Response Relationship, Drug
Humans
Laser-Doppler Flowmetry
Predictive Value of Tests
Skin blood supply
Skin drug effects
Skin physiopathology
Water Loss, Insensible drug effects
Dermatitis, Irritant diagnosis
Patch Tests
Sodium Dodecyl Sulfate adverse effects
Surface-Active Agents adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0105-1873
- Volume :
- 45
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Contact dermatitis
- Publication Type :
- Academic Journal
- Accession number :
- 11722488
- Full Text :
- https://doi.org/10.1034/j.1600-0536.2001.450506.x