Biological activity in human neutrophils of di-tripeptides, analogues of the chemotactic fMLP.

for-Met-Ser(for-Met-Leu-Phe)-Phe-OMe 1 and for-Met-Lys(for-Met-Leu-Phe)-Phe-OMe 2 were synthesized in order to investigate biological activities on human neutrophils of crosslinked di-tripeptides. Our results seem to highlight that the tested di-tripeptides (i) do not step up chemotaxis, (ii) can elicit superoxide anion production which is dependent on the nature of the residue at position 2, chosen in the tripeptide that is crosslinked to the fMLP-OMe.