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Comparison of the upper gastrointestinal effects of etodolac and aspirin in healthy dogs.
- Source :
-
The Journal of veterinary medical science [J Vet Med Sci] 2001 Oct; Vol. 63 (10), pp. 1131-3. - Publication Year :
- 2001
-
Abstract
- Fifteen healthy castrated male dogs were separated into three treatment groups that were administered etodolac, aspirin and a placebo orally, respectively. All treatments were continued for 28 days. The animals were examined endoscopically on days 0, 3, 7, 10, 14, 17, 21, 24 and 28. There were no gastrointestinal mucosal lesions in either the etodolac or the placebo group, whereas some gastric lesions developed in the aspirin group after day 17. We considered that etodolac could be used for long-term treatments in dogs with fewer side-effects on the gastric mucosa than aspirin.
- Subjects :
- Animals
Anti-Inflammatory Agents, Non-Steroidal administration & dosage
Anti-Inflammatory Agents, Non-Steroidal adverse effects
Aspirin administration & dosage
Aspirin adverse effects
Endoscopy, Gastrointestinal veterinary
Etodolac administration & dosage
Etodolac adverse effects
Gastric Mucosa pathology
Intestinal Mucosa pathology
Male
Random Allocation
Statistics, Nonparametric
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Aspirin pharmacology
Dogs metabolism
Etodolac pharmacology
Gastric Mucosa drug effects
Intestinal Mucosa drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0916-7250
- Volume :
- 63
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of veterinary medical science
- Publication Type :
- Academic Journal
- Accession number :
- 11714031
- Full Text :
- https://doi.org/10.1292/jvms.63.1131