Back to Search
Start Over
Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis-B virus does not occur in rapid acetylators.
- Source :
-
European journal of clinical pharmacology [Eur J Clin Pharmacol] 2001 Sep; Vol. 57 (6-7), pp. 461-5. - Publication Year :
- 2001
-
Abstract
- Objective: We previously found that, compared with healthy subjects. asymptomatic hepatitis-B virus (HBV) carriers displaying slow acetylator phenotype demonstrate a significant prolongation of the elimination half-life of 4-methylaminoantipyrine (MAA) and a decrease in the clearance of formation of 4-aminoantipyrine (AA) and 4-formylaminoantipyrine (FAA). However, the formation of 4-acetylaminoantipyrine (AAA) was unchanged. The present study was designed to examine the effect of the asymptomatic HBV carrier state on the metabolism of dipyrone. as a model drug, in rapid acetylators.<br />Methods: The plasma and urine concentrations of the metabolites of dipyrone were measured in eight asymptomatic HBV carriers and eight healthy subjects who had normal liver function tests, all displaying the rapid acetylation phenotype and genotype, after the administration of a 1.0-g oral dose of dipyrone.<br />Results: The following pharmacokinetic parameters were evaluated: peak plasma concentration, time to peak plasma concentration, elimination rate constant, area under the plasma concentration-time curve (0-->infinity), amount excreted (0-->infinity), renal and non-renal clearances for MAA and the clearances of formation for AA, FAA and AAA. No significant differences were found between the two subject groups.<br />Conclusion: The effect of hepatic viral carrier state on drug metabolism may vary according to metabolic pathways and genetic polymorphism.
- Subjects :
- Acetylation
Adult
Algorithms
Aminopyrine blood
Ampyrone blood
Anti-Inflammatory Agents, Non-Steroidal blood
Anti-Inflammatory Agents, Non-Steroidal chemistry
Anti-Inflammatory Agents, Non-Steroidal urine
Area Under Curve
Carrier State blood
Dipyrone blood
Dipyrone chemistry
Dipyrone urine
Female
Half-Life
Humans
Male
Metabolic Clearance Rate
Models, Biological
Aminopyrine analogs & derivatives
Aminopyrine pharmacokinetics
Ampyrone analogs & derivatives
Ampyrone pharmacokinetics
Anti-Inflammatory Agents, Non-Steroidal pharmacokinetics
Dipyrone analogs & derivatives
Dipyrone pharmacokinetics
Hepatitis B virus metabolism
Pyrazolones
Subjects
Details
- Language :
- English
- ISSN :
- 0031-6970
- Volume :
- 57
- Issue :
- 6-7
- Database :
- MEDLINE
- Journal :
- European journal of clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 11699610
- Full Text :
- https://doi.org/10.1007/s002280100341