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DOC-2/hDab-2 inhibits ILK activity and induces anoikis in breast cancer cells through an Akt-independent pathway.
- Source :
-
Oncogene [Oncogene] 2001 Oct 18; Vol. 20 (47), pp. 6960-4. - Publication Year :
- 2001
-
Abstract
- DOC-2/hDab-2 was identified due to the loss of its expression in primary ovarian cancer cells. It is believed that loss of DOC-2/hDab-2 expression is one of the early events of ovarian malignancy. These results suggest a function of DOC-2/hDab-2 as a tumor suppressor. However, it is not clear how DOC-2/hDab-2 negatively regulates cancer cell growth. In this report, we demonstrate that DOC-2/hDab-2 expression in breast cancer cells resulted in sensitivity to suspension-induced cell death (anoikis). This event was associated with the down-regulation of the integrin-linked kinase (ILK) activity. Since ILK is a key factor in regulating the cellular signaling in responding to the extracellular signals through adhesion molecules like integrins, our results indicate that DOC-2/hDab-2 may prevent tumor growth and invasion by modulating the anti-apoptotic ILK pathway.
- Subjects :
- Adaptor Proteins, Signal Transducing
Adenoviridae genetics
Apoptosis Regulatory Proteins
Breast Neoplasms pathology
Female
Genes, Tumor Suppressor
Genetic Vectors
Humans
MAP Kinase Signaling System
Proteins genetics
Proto-Oncogene Proteins physiology
Proto-Oncogene Proteins c-akt
Transfection
Tumor Cells, Cultured
Tumor Suppressor Proteins
Adaptor Proteins, Vesicular Transport
Anoikis
Breast Neoplasms enzymology
Breast Neoplasms metabolism
Protein Serine-Threonine Kinases antagonists & inhibitors
Proteins physiology
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 0950-9232
- Volume :
- 20
- Issue :
- 47
- Database :
- MEDLINE
- Journal :
- Oncogene
- Publication Type :
- Academic Journal
- Accession number :
- 11687976
- Full Text :
- https://doi.org/10.1038/sj.onc.1204873