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The use of interferon for emergency prophylaxis of marburg hemorrhagic fever in monkeys.
- Source :
-
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2001 Jul; Vol. 132 (1), pp. 686-8. - Publication Year :
- 2001
-
Abstract
- The possibility of emergency prophylaxis of Marburg hemorrhagic fever with leukocytic and recombinant interferons was studied in experiments on Cercopithecus aethiops. None of the agents protected monkeys from the action of lethal doses of Marburg virus. Recombinant interferon-alpha(2)administered according to the emergency prophylaxis schedule prolonged the mean life-span of monkeys injected with Marburg virus in doses of 100 and 1000 LD50 by 1.9 and 6.1 days, respectively.
- Subjects :
- Acute Disease
Animals
Blood virology
Body Temperature
Chlorocebus aethiops
Guinea Pigs
Humans
Interferon alpha-2
Interferon-alpha immunology
Marburg Virus Disease immunology
Marburgvirus physiology
Recombinant Proteins
Survival
Viremia
Interferon-alpha therapeutic use
Marburg Virus Disease prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 0007-4888
- Volume :
- 132
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Bulletin of experimental biology and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 11687854
- Full Text :
- https://doi.org/10.1023/a:1012540614713