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Double-strand breaks and tumorigenesis.
- Source :
-
Trends in cell biology [Trends Cell Biol] 2001 Nov; Vol. 11 (11), pp. S52-9. - Publication Year :
- 2001
-
Abstract
- The establishment of connections between biochemical defects and clinical disease is a major goal of modern molecular genetics. In this review, we examine the current literature that relates defects in the two major DNA double-strand-break repair pathways--homologous recombination and nonhomologous end-joining--with the development of human tumors. Although definitive proof has yet to be obtained, the current literature is highly suggestive of such a link.
Details
- Language :
- English
- ISSN :
- 0962-8924
- Volume :
- 11
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Trends in cell biology
- Publication Type :
- Academic Journal
- Accession number :
- 11684443
- Full Text :
- https://doi.org/10.1016/s0962-8924(01)02149-3