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Synthesis and Biological Evaluation of 1-Deoxypaclitaxel Analogues.
- Source :
-
The Journal of organic chemistry [J Org Chem] 1999 Mar 19; Vol. 64 (6), pp. 1814-1822. - Publication Year :
- 1999
-
Abstract
- The naturally occurring taxoid baccatin VI has been converted to various 1-deoxypaclitaxel derivatives by selective deacylation followed by attachment of the C-13 side chain. The bioactivities of the resulting analogues were determined in both tubulin polymerization and cytotoxicity assays, and several analogues with activity comparable to that of paclitaxel were discovered. It thus appears that the 1-hydroxyl group is not necessary for the activity of paclitaxel.
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 64
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 11674269
- Full Text :
- https://doi.org/10.1021/jo981406l