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Effect of chronic administration of flesinoxan and fluvoxamine on freezing behavior induced by conditioned fear.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 2001 Aug 03; Vol. 425 (1), pp. 43-50. - Publication Year :
- 2001
-
Abstract
- The present study investigated the acute effects of flesinoxan (a selective 5-HT(1A) receptor agonist), fluvoxamine (a selective serotonin reuptake inhibitor) and their co-administration on the expression of conditioned freezing, and index of anxiety in rats. This study also examined the acute effects of fluvoxamine and flesinoxan following chronic flesinoxan or chronic fluvoxamine on the expression of conditioned freezing. Acute administration of flesinoxan (s.c.; 0.1-3 mg/kg) reduced freezing dose dependently, and fluvoxamine (i.p.) at a high dose (60 mg/kg) reduced freezing significantly. Acute co-administration of fluvoxamine (30 mg/kg) and flesinoxan (0.3 mg/kg) showed an additive inhibitory effect on freezing. Chronic flesinoxan treatment (0.3 mg/kg, for 13 days) did not affect the inhibitory effect of acute flesinoxan treatment, but enhanced that of acute fluvoxamine (30 mg/kg) on conditioned freezing. Chronic fluvoxamine treatment (30 mg/kg, for 13 days) enhanced the inhibitory effect of acute fluvoxamine (30 mg/kg) and the inhibitory effect of acute flesinoxan (0.3 mg/kg) on conditioned freezing. These results suggest that co-administration of a selective serotonin reuptake inhibitor and a 5-HT(1A) receptor agonist is useful for the treatment of anxiety disorders.
- Subjects :
- Analysis of Variance
Animals
Conditioning, Psychological physiology
Dose-Response Relationship, Drug
Male
Motor Activity drug effects
Rats
Rats, Sprague-Dawley
Behavior, Animal drug effects
Fear psychology
Fluvoxamine pharmacology
Piperazines pharmacology
Serotonin Receptor Agonists pharmacology
Selective Serotonin Reuptake Inhibitors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 425
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 11672573
- Full Text :
- https://doi.org/10.1016/s0014-2999(01)01159-1