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Spectrophotometric methods for the determination of ritodrine hydrochloride and its application to pharmaceutical preparations.
- Source :
-
Farmaco (Societa chimica italiana : 1989) [Farmaco] 2001 Aug; Vol. 56 (8), pp. 615-9. - Publication Year :
- 2001
-
Abstract
- Two simple and sensitive spectrophotometric methods are described for the determination of ritodrine hydrochloride (RTH) in both pure and dosage forms. The methods are based on the interaction of diazotised p-nitroaniline (DPNA) and sulphanilic acid (DSNA) with RTH in an alkaline medium. The resulting azo dyes are measured at 480 nm (for the DPNA method) and at 440 nm (for the DSNA method) and are stable for more than 1 h. The optimum reaction conditions and other analytical parameters are evaluated. A study of the effect of commonly associated excipients and additives do not interfere with the determinations. Statistical analysis of results indicates that the methods are precise and accurate.
Details
- Language :
- English
- ISSN :
- 0014-827X
- Volume :
- 56
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Farmaco (Societa chimica italiana : 1989)
- Publication Type :
- Academic Journal
- Accession number :
- 11601648
- Full Text :
- https://doi.org/10.1016/s0014-827x(01)01069-2