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Efficacy of a nelfinavir- and nevirapine-containing salvage regimen.
- Source :
-
HIV clinical trials [HIV Clin Trials] 2000 Jul-Aug; Vol. 1 (1), pp. 7-12. - Publication Year :
- 2000
-
Abstract
- Purpose: In this study, our purpose was to assess the efficacy of nelfinavir- and nevirapine-containing salvage regimens in nonnucleoside reverse transcriptase inhibitor (NNRTI)-naive patients virologically failing a protease inhibitor (PI)-based combination.<br />Method: A retrospective case note review of all patients virologically failing their PI-based combination who were switched to a regimen containing both nelfinavir (1 g t.d.s.) and nevirapine (200 mg b.d.). CD4 cell counts and viral loads were monitored. Genotypic analysis was performed using RT-PCR sequencing.<br />Results: Nineteen patients commenced a salvage regimen containing nelfinavir and nevirapine. Five patients also changed at least one nucleoside reverse transcriptase inhibitor (NRTI), although in one case this represented recycling. Thirty-eight percent (6/16) of patients achieved a viral load below the level of detection (BLD; <200 copies/mL; complete responders [CR]), 3 achieved <20 copies/mL. Five patients achieved > or =1 log drop (partial responders [PR]) that was not sustained over follow-up, and five failed to respond to therapy (nonresponders [NR]). CRs tended to have wild-type NNRTI and PI sequences relative to PRs and NRs.<br />Conclusion: In heavily pretreated patients, a nelfinavir-and nevirapine-containing salvage regimen resulted in a virological response in 38% of patients that was sustained in 31% over 63 weeks.
- Subjects :
- Adult
CD4 Lymphocyte Count
Drug Resistance, Viral genetics
Drug Therapy, Combination
HIV Infections immunology
HIV Infections virology
HIV-1 genetics
HIV-1 physiology
Humans
Male
Middle Aged
Treatment Outcome
Viral Load
Anti-HIV Agents therapeutic use
HIV Infections drug therapy
Nelfinavir therapeutic use
Nevirapine therapeutic use
Reverse Transcriptase Inhibitors therapeutic use
Salvage Therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1528-4336
- Volume :
- 1
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- HIV clinical trials
- Publication Type :
- Academic Journal
- Accession number :
- 11590484
- Full Text :
- https://doi.org/10.1310/64pf-wk1q-96y5-axjq