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Graft-versus-leukemia for AKR spontaneous leukemia-lymphoma.
- Source :
-
Transplantation proceedings [Transplant Proc] 1976 Dec; Vol. 8 (4), pp. 569-74. - Publication Year :
- 1976
-
Abstract
- Adoptive immunotherapy in the form of a transient graft of mismatched DBA/2 BM + LN cells was used in combination with several chemoradiotherapy regimens to treat AKR mice bearing advanced SLL. Leukemic mice treated in this manner had a significant prolongation of their MST and significantly higher survival rates 60 and 90 days posttreatment than corresponding control groups. Syngeneic- or allogeneic-matched cells did not provide substantial GVL effect. An inverse relationship that influenced survival was observed between the radiation dose and the dose of GVL effector cells used to treat leukemic AKR mice in the treatment model. Recurrence leukemia remains a major problem.
- Subjects :
- Amphotericin B therapeutic use
Animals
Bone Marrow Cells
Bone Marrow Transplantation
Cyclophosphamide therapeutic use
Leukemia, Experimental mortality
Lymph Nodes transplantation
Lymphocyte Culture Test, Mixed
Lymphoma mortality
Mice
Mice, Inbred AKR
Mice, Inbred DBA
Nitroso Compounds therapeutic use
Radiation Chimera
Time Factors
Transplantation, Homologous
Graft vs Host Reaction
Leukemia, Experimental immunology
Lymphoma immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0041-1345
- Volume :
- 8
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Transplantation proceedings
- Publication Type :
- Academic Journal
- Accession number :
- 11589