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Effect of exercise training on serum leptin levels in type 2 diabetic patients.
- Source :
-
Metabolism: clinical and experimental [Metabolism] 2001 Oct; Vol. 50 (10), pp. 1136-40. - Publication Year :
- 2001
-
Abstract
- To evaluate the effect of exercise training on serum leptin levels 50 sedentary subjects with type 2 diabetes were enrolled in either 6 weeks of aerobic exercise training with diet therapy (n = 23) or diet therapy alone (n = 27). The training program consisted of walking and cycle ergometer exercise for 1 hour at least 5 times per week, with the intensity of exercise maintained at 50% of maximum oxygen uptake. Serum leptin levels decreased significantly in the exercise training (TR) group (7.2 +/- 3.6 to 4.6 +/- 2.5 ng/mL, P <.05), but not in the sedentary (SED) group (6.9 +/- 3.4 to 5.6 +/- 2.9 ng/mL). Leptin levels standardized for percentage body fat (dividing serum leptin level by percentage body fat) after treatment were lower in the TR subjects compared with the SED subjects. Body weight and percentage body fat decreased in all patients; however, no significant changes were observed in either group. Fasting concentrations of plasma insulin and cortisol and the urinary excretion of 17-hydroxycorticosteroid (17-OHCS) did not differ between the groups either before or after treatment. Fasting plasma glucose and hemoglobin A(1c) (HbA(1c)) improved significantly in both groups, although no significant differences were observed between the groups either before or after treatment. Ventilatory threshold increased significantly in the exercise training subjects. This study demonstrates that exercise training in type 2 diabetic subjects reduces serum leptin levels independent of changes in body fat mass, insulin, or glucocorticoids.<br /> (Copyright 2001 by W.B. Saunders Company)
- Subjects :
- 17-Hydroxycorticosteroids urine
Adipose Tissue
Body Mass Index
Body Weight
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 therapy
Energy Metabolism
Exercise Therapy
Fasting
Female
Humans
Hydrocortisone blood
Insulin blood
Male
Time Factors
Diabetes Mellitus, Type 2 physiopathology
Exercise physiology
Leptin blood
Subjects
Details
- Language :
- English
- ISSN :
- 0026-0495
- Volume :
- 50
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Metabolism: clinical and experimental
- Publication Type :
- Academic Journal
- Accession number :
- 11586483
- Full Text :
- https://doi.org/10.1053/meta.2001.26745