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Selective estrogen receptor modulation and reduction in risk of breast cancer, osteoporosis, and coronary heart disease.
- Source :
-
Journal of the National Cancer Institute [J Natl Cancer Inst] 2001 Oct 03; Vol. 93 (19), pp. 1449-57. - Publication Year :
- 2001
-
Abstract
- The recognition of selective estrogen receptor modulation in the laboratory has resulted in the development of two selective estrogen receptor modulators (SERMs), tamoxifen and raloxifene, for clinical application in healthy women. SERMs are antiestrogenic in the breast but estrogen-like in the bones and reduce circulating cholesterol levels. SERMs also have different degrees of estrogenicity in the uterus. Tamoxifen is used specifically to reduce the incidence of breast cancer in premenopausal and postmenopausal women at risk for the disease. In contrast, raloxifene is used specifically to reduce the risk of osteoporosis in postmenopausal women at high risk for osteoporosis. The study of tamoxifen and raloxifene (STAR) trial is currently comparing the ability of these SERMs to reduce breast cancer incidence in high-risk postmenopausal women. There is intense interest in understanding the molecular mechanism(s) of action of SERMs at target sites in a woman's body. An understanding of the targeted actions of this novel drug group will potentially result in the introduction of new multifunctional medicines with applications as preventive agents or treatments of breast cancer and endometrial cancer, coronary heart disease, and osteoporosis.
- Subjects :
- Adult
Aged
Bone and Bones drug effects
Breast drug effects
Breast Neoplasms chemistry
Breast Neoplasms epidemiology
Cardiovascular System drug effects
Cinnamates pharmacology
Clinical Trials as Topic
Coronary Disease epidemiology
Endometrial Neoplasms chemically induced
Estrogen Replacement Therapy
Female
Heart drug effects
Hot Flashes chemically induced
Humans
Middle Aged
Models, Biological
Organ Specificity
Osteoporosis epidemiology
Postmenopause
Premenopause
Prospective Studies
Protein Structure, Tertiary drug effects
Raloxifene Hydrochloride adverse effects
Raloxifene Hydrochloride pharmacology
Raloxifene Hydrochloride therapeutic use
Randomized Controlled Trials as Topic
Receptors, Estrogen analysis
Receptors, Estrogen drug effects
Risk
Risk Assessment
Selective Estrogen Receptor Modulators adverse effects
Selective Estrogen Receptor Modulators pharmacology
Stilbenes pharmacology
Tamoxifen adverse effects
Tamoxifen pharmacology
Tamoxifen therapeutic use
Thrombophilia chemically induced
Transcription, Genetic drug effects
Breast Neoplasms prevention & control
Coronary Disease prevention & control
Osteoporosis prevention & control
Selective Estrogen Receptor Modulators therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0027-8874
- Volume :
- 93
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- Journal of the National Cancer Institute
- Publication Type :
- Academic Journal
- Accession number :
- 11584060
- Full Text :
- https://doi.org/10.1093/jnci/93.19.1449