Back to Search
Start Over
Age-related changes in the N-methyl-D-aspartate receptor binding sites within the human basal ganglia.
- Source :
-
Experimental neurology [Exp Neurol] 2001 Oct; Vol. 171 (2), pp. 391-404. - Publication Year :
- 2001
-
Abstract
- The present study examined the regional differences in dopamine transporter binding sites and NMDA receptor complex binding based on autoradiographic images obtained in postmortem sections of human normal brain tissues. In middle-aged control tissues, high and comparable levels of [(3)H]CFT binding were observed in the caudate nucleus, putamen, and accumbens nucleus without significant alteration along the rostrocaudal axis and ventral and dorsal parts of these nuclei. In aging normal brain tissues, dopamine binding sites for [(3)H]CFT were significantly reduced in the caudate nucleus, putamen, and accumbens nucleus. l-[(3)H]Glutamate, [(3)H]MK-801, and [(3)H]glycine binding to the NMDA receptor complex was lower in aging brain tissues than in middle-aged controls. Significant correlation did occur between age and [(3)H]CFT binding and between age and l-[(3)H]glutamate, [(3)H]MK-801, and [(3)H]glycine binding sites. These results demonstrate that the basal ganglia have age-associated reductions in dopamine transporter uptake and NMDA receptors. These data support hypoactive activity of the NMDA receptor complex system with advancing age. The dopamine transporter uptake and NMDA receptors appear to be vulnerable to the aging process in the basal ganglia.<br /> (Copyright 2001 Academic Press.)
- Subjects :
- Adult
Aged
Autoradiography
Caudate Nucleus growth & development
Caudate Nucleus metabolism
Cause of Death
Cocaine metabolism
Dizocilpine Maleate metabolism
Dopamine Uptake Inhibitors metabolism
Female
Glutamic Acid metabolism
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Nucleus Accumbens growth & development
Nucleus Accumbens metabolism
Putamen growth & development
Putamen metabolism
Radioligand Assay
Aging
Basal Ganglia growth & development
Basal Ganglia metabolism
Cocaine analogs & derivatives
Receptors, N-Methyl-D-Aspartate metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0014-4886
- Volume :
- 171
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Experimental neurology
- Publication Type :
- Academic Journal
- Accession number :
- 11573991
- Full Text :
- https://doi.org/10.1006/exnr.2001.7737