Back to Search
Start Over
Autocrine role of macrophage inflammatory protein-1 beta in human T-cell lymphotropic virus type-I tax-transfected Jurkat T-cells.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2001 Oct 05; Vol. 287 (4), pp. 910-3. - Publication Year :
- 2001
-
Abstract
- The interaction of human T-cell lymphotropic virus I (HTLV-I) tax gene with host cell factors plays an important role in the maintenance of the transformed state. There have been numerous reports that have demonstrated the role of tax in transactivating several cytokines. In this study, we show that upon mitogen stimulation, macrophage inflammatory protein-1 beta (MIP-1beta) is expressed and secreted in tax-transfected Jurkat cells. Furthermore, expression of CC-chemokine receptor-5 (CCR5) mRNA in these cells suggests an autocrine role for MIP-1beta in HTLV-I-infected T-cells. These results, coupled with our earlier observations, demonstrate the influence that extracellular Tax protein might have on modulating host chemokines for proliferation and transformation of uninfected cells.<br /> (Copyright 2001 Academic Press.)
- Subjects :
- Chemokine CCL4
Enzyme-Linked Immunosorbent Assay
Gene Products, tax metabolism
Humans
Jurkat Cells
Lymphocyte Activation
Macrophage Inflammatory Proteins genetics
Phytohemagglutinins pharmacology
Receptors, CCR5 genetics
Receptors, CCR5 metabolism
Tetradecanoylphorbol Acetate pharmacology
Transfection
Autocrine Communication physiology
Genes, pX
Human T-lymphotropic virus 1 genetics
Macrophage Inflammatory Proteins metabolism
T-Lymphocytes metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0006-291X
- Volume :
- 287
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 11573951
- Full Text :
- https://doi.org/10.1006/bbrc.2001.5671